Methyldrostanolone was first described in 1959. This steroid was developed by the international pharmaceuticals giant Syntex, alongside such other well-known anabolic agents as drostanolone propionate and oxymetholone. Unlike drostanolone and oxymetholone, however, this steroid (at least in its basic form) was never released as a medicinal product. It was only sold for a brief period of time as a modified hormone called dimethazine. Dimethazine is made from two molecules of methyldrostanolone that are bonded together, which are later metabolically separated to yield free methyldrostanolone. So while technically methyldrostanolone itself was never sold as a prescription agent, we can say that the drug was one utilized medicinally (for more information see the Roxilon drug profile). Otherwise, the methyldrostanolone molecule remained an obscure research steroid only, and was never itself approved for use in humans.
Methyldrostanolone was released in early 2005 as an over the counter "grey market" anabolic steroid in the United States. The drug was being sold without restrictions as a nutritional supplement product, barring some minimum age disclaimers by the manufacturer. No State or Federal laws identify this drug as an anabolic steroid, which remove the legalities associated with being a Class III controlled substance like other steroids. This is simply due to the fact that methyldrostanolone was not in commerce at the time such laws were written, and was unknown to lawmakers. It was never legal to sell as a dietary supplement, however, and in late 2005 the FDA angrily acknowledged methyldrostanolone was being sold on the sports supplement market. In early 2006, the FDA sent letters to the manufacturer and a distributor demanding it be pulled from commerce. Superdrol has since been discontinued.
How is Superdrol Supplied
Methyldrostanolone was never sold as a prescription drug preparation. When sold as a nutritional supplement, it was generally in the form of capsules containing 10 mg of steroid each.
Structural Characteristics of Superdrol
Methyldrostanolone is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, and 2) the introduction of a methyl group at carbon-2 (alpha), which considerably increases the anabolic strength of the steroid by heightening its resistance to metabolism by the 3-hydroxysteroid dehydrogenase enzyme in skeletal muscle tissue.
Superdrol Side Effects (Estrogenic)
Methyldrostanolone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, methyldrostanolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.
Superdrol Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Methyldrostanolone is a steroid with relatively low androgenic activity relative to its tissuebuilding actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. Note that methyldrostanolone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride.
Superdrol Side Effects (Hepatotoxicity)
Methyldrostanolone is a c7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C117-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Note that although no human data can be found to make reference of, doses of 10 mg and 20 mg per day have been sufficient to produce high elevations of liver enzymes in consumers, as reported by private lab test results. Also, a small number of serious adverse events relating to liver toxicity have been reported with the use of this substance. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.
Superdrol Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Methyldrostanolone has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil .or a product with comparable ingredients is also recommended.
Superdrol Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Superdrol Administration (Men)
Methydrostanolone was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage of methyldrostanolone for physique- or performance-enhancing purposes seems to begin in the range of 10-20 mg per day, taken for no longer than 6 or 8 weeks. At this level it seems to impart a measurable muscle-building effect, which is usually accompanied by fat loss and increased definition. Don't expect to gain 30 pounds on this agent (its name, which is short for "Super Anadrol," is more marketing than reality), but many do walk away with more than 10 pounds of solid muscle gain when using this agent alone.
In determining an optimal daily dosage, some do find the drug to be measurably more effective when venturing up to the 30 mg range. Potential hepatotoxicity should definitely be taken into account with such use, however. To avoid further escalating liver strain, 20 mg daily of methyldrostanolone is sometimes stacked with a nontoxic injectable steroid, such as testosterone for massbuilding phases of training, or nandrolone or boldenone for more lean tissue gain and definition, instead of simply increasing the dosage. The drug also works well in cutting cycles, where its lack of estrogenicity is highly favored. Often it is combined here with a non-aromatizable injectable steroid like Primobolan or Parabolan.
Superdrol Administration (Women)
Methyldrostanolone was never approved for use in humans. Prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage would fall around 2.5 mg per day, taken in cycles lasting no more than 4-6 weeks to minimize the chance for virilization. The main point of contention with females is probably going to be the 10 mg per capsule dosage, which is far too high to use. Application would require opening each capsule and splitting the powdered contents up into 4 separate doses. As with all steroids, virilization is still possible.
Methyldrostanolone is not available as a prescription drug product. This steroid may be found in many underground steroid products.
Wlliam Llewellyn (2017) - Anabolics