Chloromethylandrostenediol (CMA) is an oral anabolic steroid derived from testosterone. This agent is closest in structure to chloromethyltestosterone, which is a non-aromatizable and milder analog of methyltestosterone. In animal assays chloromethyltestosterone displayed about 30-50% of the anabolic activity of methyltestosterone, with about 10% of the accompanying androgenic activity. CMA, however, carries a 3-beta hydroxyl group instead of the common 3-keto that facilitates receptor binding,-which makes it somewhat weaker than chloromethyltestosterone in comparison. Normal metabolic pathways should yield some amount of chloromethyltestosterone after ingestion, although most of the activity we see with this steroid is expected to be intrinsic. Chloromethylandrostenediol is a primarily anabolic but fairly weak steroid milligram for milligram, although it does possess enough potency to be an effective lean mass building drug.
|Brand name||Promagnon, Chloromethylandrostenediol|
|Androgenic||no data available|
|Anabolic||no data available|
|Progestational Activity||no data available (low)|
Chloromethylandrostenediol appears to be a new chemical entity, although its structure is fairly basic in light of other similar steroids. The drug was first described in 2005, when a new company called Peak Performance Laboratories introduced it to the U.S. supplement market under the brand name Promagnon. This steroid product was designed by Bruce Kneller, the same person that developed the widely selling and highly regarded designer compound Halodrol. Like Halodrol, Promagnon was considered a "grey market" product because it contained a steroid that was not specifically listed as a controlled substance in the U.S. It would, however, be considered an unapproved new drug in the eyes of the Food and Drug Administration, which by law cannot be sold. Although no specific action was taken against Peak Performance Laboratories for their sale of chloromethylandrostenediol, the company likely recognized that an FDA response would eventually come, and voluntarily discontinued the sale of Promagnon in late 2006.
How is Promagnon Supplied
Chloromethylandrostenediol is not available as a prescription drug product. When manufactured as a supplement, it contained 25 mg of steroid per tablet.
Structural Characteristics of Promagnon
Chloromethylandrostenediol is a modified form of testosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, 2) the attachment of a chloro group at carbon 4, which inhibits steroid aromatization and reduces relative androgenicity, and 3) the substitution of 3-keto with 3-hydroxyl, which reduces relative steroid activity.
Promagnon Side Effects (Estrogenic)
Chloromethylandrostenediol is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.
Promagnon Side Effects (Androgenic)
Although chloromethylandrostenediol is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. For those with a genetic predisposition, anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, body and facial hair growth, and clitoral enlargement. Note that chloromethylandrostenediol is not extensively metabolized by the 5-alpha reductase enzyme, so its relative androgenicity is not greatly altered by the concurrent use of finasteride or dutasteride.
Promagnon Side Effects (Hepatotoxicity)
Chloromethylandrostenediol is a cl 7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C1.7-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of cl 7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating Jiver strain.
Promagnon Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Chloromethylandrostenediol has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Promagnon Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Promagnon Administration (General)
Prescribing guidelines generally advise that oral steroids can be taken with or without meals. The difference in bioavailability is generally not regarded as substantial. However, a 2016 study on newborn infants did find the absorption of oxandrolone to be significantly improved when dissolved directly in fat (MCT oil). If the diet includes considerable fat content, taking this oral steroid with meals might be more advantageous.
Promagnon Administration (Men)
Chloromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. When used for physique- or performance-enhancing purposes, an effective oral daily dosage falls in the range of 50-100 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for noticeable increases in lean muscle mass and strength. Higher doses will impart a stronger effect, but are also more likely to present significant hepatotoxicity.
Promagnon Administration (Women)
Chloromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. Although this drug is primarily anabolic in nature, safe dosage recommendations for women have not been established. This steroid is, therefore, generally not recommended to women for physique- or performanceenhancing purposes.
Chloromethylandrostenediol is not available as a prescription drug product. It may be found in a small number of underground preparations.
Wlliam Llewellyn (2017) - Anabolics