Primobolan Depot is an injectable version of the steroid methenolone. This is the same constituent in Primobolan orals (methenolone acetate), although here an enanthate ester is used to slow the steroid’s release from a site of injection. Methenolone enanthate offers a similar pattern of steroid release as testosterone enanthate, with blood hormone levels remaining markedly elevated for approximately 2 weeks. Methenolone itself is a moderately strong anabolic steroid with very low androgenic properties. Its anabolic effect is considered to be slightly less than Deca-Durabolin (nandrolone decanoate) on a milligram for milligram basis. Methenolone enanthate is most commonly used during cutting cycles, when lean mass gain, not a raw mass increase, is the main objective.
|Brand name||Primobolan depot, Methenolone enanthate, Primobol, Primobolan depot-mite|
|Progestational Activity||no data available (low)|
Methenolone Enanthate History
Methenolone was first described in 1960. Squibb introduced the drug (as methenolone enanthate) to the U.S. prescription drug market in 1962, sold for a very short time in the U.S. under the brand name of Nibal Depot. Rights to the drug were given to Schering in West Germany (now Bayer) that same year, and Nibal Depot soon disappeared from the U.S. market. Schering would sell methenolone enanthate under its new and ultimately most recognizable brand name, Primobolan Depot. During the 1960s and ’70’s Primobolan Depot was available mainly in Europe, including such countries as Switzerland, Italy, Germany, Austria, Belgium, France, Portugal, and Greece.
Schering maintained patent control over methenolone enanthate until the late 1970s. Before its patents expired, Schering had rigorously protected its intellectual property rights against any potential infringement, even in the U.S. market, where the company had not been marketing Primobolan Depot. Although methenolone enanthate has not been available for commercial sale in the United States for decades, it has technically retained its status as an FDA-approved drug.
Primobolan Depot is typically prescribed as a lean tissue building anabolic agent, often used in cases where body wasting has occurred secondary to an operation, prolonged infection, wasting disease, aggressive corticosteroid administration, or convalescence. Some clinicians also prescribe this agent for treating osteoporosis, sarcopenia (the natural loss of muscle mass with aging), certain cases of chronic hepatitis, and breast carcinoma (usually as a secondary medication following other therapies). The steroid has also been used to promote weight gain in underweight premature infants and children in clinical studies, and was able to do so effectively and without signs of toxicity or undesirable effects. Athletes have long favored the combined strong anabolic, weak androgenic, and non-estrogenic nature of this drug, which makes it very desirable for building lean muscularity without side effects.
Although Primobolan Depot demonstrated a good record of clinical safety, by the 1990s Schering had grown to be a multinational pharmaceutical giant, and was inevitably forced to reexamine its global steroid offerings in light of public concerns about sports doping. Primobolan Depot would be voluntarily withdrawn from most of the countries that had originally sold it. Today, the brand is sold in just a handful of countries including Spain, Turkey, Japan, Paraguay, and Ecuador. In spite of its limited supply, Bayer has remained (nearly) the exclusive producer of methenolone enanthate in the human drug business worldwide. In recent years, however, methenolone enanthate has shown up in a small number of other preparations, most from underground or export-only companies.
How is Methenolone Enanthate Supplied
All forms of Bayer Primobolan Depot are packaged in 1 mL glass ampules and contain 100 mg of methenolone enanthate. Composition and dosage of other brands may vary by country and manufacturer.
Structural Characteristics of Methenolone Enanthate
Methenolone is a derivative of dihydrotestosterone. It contains one additional double bond between carbons 1 and 2, which helps to stabilize the 3-keto group and increase the steroid’s anabolic properties, and an additional 1-methyl group, which gives the steroid some protection against hepatic metabolism. Primobolan Depot makes use of methenolone with a carboxylic acid ester (enanthoic acid) attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) methenolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.
Methenolone Enanthate Side Effects (Estrogenic)
Methenolone is not aromatized by the body, and is not measurably estrogenic. Estrogenlinked side effects should not be seen when administering this steroid. Sensitive individuals need not worry about developing gynecomastia, nor should they be noticing any appreciable water retention with this drug. The increase seen with methenolone should be quality muscle mass, not the smooth bulk that often accompanies steroids open to aromatization. During a cycle, the user should additionally not notice strong elevations in blood pressure, as this effect is also related (generally) to estrogen and water retention. Methenolone is a steroid most favored during cutting phases of training, when water and fat retention are major concerns, and sheer mass not the central objective.
Methenolone Enanthate Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Methenolone is still a very mild steroid, however, and strong androgenic side effects are typically related to higher doses. Women often find this preparation an acceptable choice, observing it to be a very comfortable and effective anabolic.
Methenolone Enanthate Side Effects (Hepatotoxicity)
Methenolone is not considered a hepatotoxic steroid; liver toxicity is unlikely. Studies have failed to produce appreciable changes in markers of hepatic stress when the drug was given in therapeutic levels.
Methenolone Enanthate Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Methenolone should have a stronger negative effect on the hepatic management of cholesterol than testosterone or nandrolone due to its non-aromatizable nature, but a much weaker impact than c-17 alpha alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Methenolone Enanthate Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. At a moderate dosage of 100-200 mg weekly, methenolone should offer measurably less testosterone suppression than an equal dose of nandrolone or testosterone, due to its non-aromatizable nature. If used for less than eight weeks, hormonal recovery should not be a protracted experience.
Methenolone Enanthate Administration (Men)
The prescribing guidelines for Primobolan Depot recommend a maximum dosage of 200 mg at the onset of therapy, and a continuing dosage of 100 mg every week. Prolonged administration protocols generally call for a 100 mg dosage every 1-2 weeks, or 200 mg every 2-3 weeks. The usual administration protocols among male athletes call for a 200-400 mg per week dosage, which is taken for 6 to 12 weeks, which is sufficient to promote very noticeable increases in lean muscle tissue. It is, however, not unusual to see the drug taken in doses as high as 600 mg per week or more, although such amounts are likely to highlight a more androgenic side of methenolone, as well as exacerbate its negative effects on serum more androgenic side of methenolone, as well as exacerbate its negative effects on serum lipids.
Methenolone enanthate is often stacked with other (typically stronger) steroids in order to obtain a faster and more enhanced effect. During a dieting or cutting phase, a nonaromatizing androgen like Halotestin or trenbolone can be added. The stronger androgenic component here should help to bring about an added density and hardness to the muscles. On the other hand, one might add another mild anabolic steroid such as stanozolol. The result of such a combination should again be a notable increase in muscle mass and hardness, which still should not be accompanied by greatly increased side effects. Methenolone enanthate is also used effectively during bulking phases of training. In such a scenario, the addition of testosterone or boldenone would prove quite effective for adding new muscle mass without presenting any notable hepatotoxicity to the user.
Methenolone Enanthate Administration (Women)
The prescribing guidelines for Primobolan Depot do not offer separate dosing recommendations for women, although it was indicated that women who were pregnant, or may become pregnant, should not use the drug. Female athletes generally respond well to a dosage of 50-100 mg per week. If both oral and injectable versions are available, the oral is often given preference, as it allows for greater control over blood hormone levels. Additionally, some women choose to include Winstrol Depot (25 mg twice per week) or Oxandrolone (7.5-10 mg daily), and with it receive a greatly enhanced anabolic effect. Androgenic activity can be a concern with such dosing, however, and should be monitored closely. If stacking, it would be best to use a much lower starting dosage for each drug than if they were to be used alone. This is especially good advice if you are unfamiliar with the effect such a combination may have on you. A popular recommendation would also be to first experiment by stacking with oral Primobolan, and later venture into the injectable if this is still necessary.
Methenolone Enanthate Availability
Pharmaceutical preparations containing methenolone enanthate remain scarce. The bulk of the supply for this compound comes from underground steroid manufacturers. In reviewing some of the remaining products and changes in the global pharmaceutical market, we have made the following observations.
Bayer took control of Schering AG in December 2006. Following this acquisition, the Schering Primobolan Depot products were transitioned over to the Bayer brand and logo. The company produces the drug in limited markets only, most notably Turkey and Spain. These products have historically been the subject of large volume counterfeiting, however, so consumers should be especially careful with brand name Primobolan Depot products.
Balkan Pharmaceuticals (Moldova) makes the product Primobol. It is prepared in both 1 mL ampules and multi-dose vials.
Primobolan is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
Magnus Pharmaceuticals makes the product Primobolan primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
Primobolan Depot is similar to the acetate tablets with a few differences. Though it is a predominantly anabolic steroid, being a DHT derivative it also maintains some androgenic qualities. For this reason, it does have virilizing aspects to consider. This explains the improved strength and harder appearance polled users obtained in part. Naturally since it does not convert to estrogens, induced low water retention and a distinct lack of gyno and female pattern fat deposits was noted as avoided. In fact, the drug does theoretically act as an anti-estrogen to a lesser extent.
Women reported they were able to avoid some virilizing aspects with Proscar.
Most first time male (AAS novices) users reported an 8-16 lb gain after 6-8 weeks of 200mg weekly dosages. The new muscle was of a high quality and usually was retained quite well after discontinuance. This may have been due to Primobolan depot having only a slight negative effect upon the Hypothalamic-Pituitary-Testes-Axis (HPTA). In short, this drug was noted to only slightly shut down natural testosterone production and therefore there was not a significant lack of testosterone or an elevation in circulatory estrogen post- cycle. This was especially true if dosages were kept at 200- 300-mg weekly for no more than 6-8 weeks for males. (Women don't have testes, remember?). For this reason, older males made excellent and reasonably permanent gains with little interruption in their already lower natural androgen production. For stacks focusing on this issue, Oxandrolone and Android were said to work very well with Primobolan Depot. Primobolan based stacks containing nandrolones and/or Equipoise were commonly utilized for this purpose also.
A point of interest: Primobolan Depot (like Winstrol Depot) has been noted to possess excellent site- injection qualities. This means that a lagging body part became the injection site for dosages. Most who used this type of protocol did so after training that body part to avoid bruising.
Women actually should not have used high dosages of any DHT product or derivative. DHT has excellent hardening effects, but also has masculinizing aspects. An often noted as safer method for use of such drugs was to also co-administer a 5-ALFAREDUCTASE INHIBITOR such as Proscar. Its active ingredient is Finasteride which blocks testosterone's conversion to DHT. Yes, that is the pill guys take to stop their hair - line from receding. 1mg daily was said be enough when women stayed in the 50-200mg weekly dosage range when using Primobolan Depot.
Since Primobolan Depot actually has an active-life of closer to two weeks, injections were commonly administered weekly by those whom reported lower dosage use. But due to predominantly 50-mg/ml ampules being the most available a 4-ml/200mg injection “hurt” to an excessive degree for those whom employed the higher dosage protocols. So twice weekly injections was the normal method chosen.
It was my experience that Primobolan was one of the few steroids capable of increasing lean mass during calorie restricted periods therefore remaining effective even in calorie deficit induced catabolic environments. This drug is an Enanthate ester and should provide an 8 day active life. Strangely enough it does provide the above listed active-life range though the ester is an enanthate.
Newbies Research Guide reference
Is a registered trade make of Schering A/G avaiable in 50 mg/cc from Mexico and 100 mg/cc from Europe. Primo is the “Cleanest and Gentles” anabolic steroid, will not aromatize, non-toxic, low in androgens. Primo may be taken by both Men and Women. Dosages for men are 100-300 mg/week, Women 1/2 dosage. Primo is the only steroid that works well on a low calorie diet. Effective for bulking, but tends to harden and add muscle tone more that build big muscles. Primo great when added to a cycle (stacked) with other steroids, it tends to lessen water retention and harshness when stacked with more heavy duty testosterone injectables, like Omnadren/sustanon 250, Cypoinate/propionate, ect. Primo is an analog immune-stimulating steroid used be people with Aids and other with depressed immune systems to build up the immune system and other with depressed immune systems to build up the immune system and add lean muscle mass. Primo is not legally allowed by the FDA in the United States,but it is one of the finest steroids in the world today.testosterone injectables, like Omnadren/sustanon 250, Cypoinate/propionate, ect. Primo is an analog immune-stimulating steroid used be people with Aids and other with depressed immune systems to build up the immune system and other with depressed immune systems to build up the immune system and add lean muscle mass. Primo is not legally allowed by the FDA in the United States,but it is one of the finest steroids in the world today.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Newbies Research Guide