Bromocriptine Mesylate History
Bromocriptine has been used widely in clinical medicine for its indicated used since the 1970s. It is also much more widely distributed than its counterpart medication cabergoline, which is used for a similar set of clinical indications. In the U.S., the most common brand name is Parlodel, which is sold by Novartis. The drug is available in dozens of countries, and is sold under a similarly large number of different trade names including (but not limited to) Bromed, Criten, Grifocriptina, Bromo-Kin, Pavidel, and Gynodel. Bromocriptine remains a common medication today in most developed nations for its intended therapeutic uses.
How is Bromocriptine Mesylate Supplied
Bromocriptine mesylate is most commonly supplied in tablets of 2.5 mg and 5 mg. The doses are expressed in terms of base bromocriptine, so each 2.5 mg tablet contains 2.87 mg of bromocriptine mesylate.
Structural Characteristics of Bromocriptine Mesylate
Bromocriptine mesylate is an ergot derivative with the chemical designation (5’S)-2-bromo- 12’-hydroxy-2’-(1- methylethyl)-5’-(2-methylpropyl)-ergotaman-3’,6’,18-trione methanesulphonate.
Bromocriptine Mesylate Side Effects
Bromocriptine can produce a number of unwanted side effects, the most notable being low blood pressure, dizziness, confusion and nausea. These side effects do tend to be dose related, with the low recommended doses used in bodybuilding are not likely to be much trouble for many. Further, initial nausea sometimes goes away after a couple of applications, once the user becomes accustomed to the drug. However, the strong incidence of any unwelcome side effects should warrant discontinuing therapy, especially if blood pressure is becoming negatively affected (too low a drop). Less common adverse reactions include anxiety, dry mouth, edema, seizures, fatigue, headache, lethargy, nasal congestion, rash, elevated liver enzymes, and changes in urinary frequency.
Bromocriptine Mesylate Administration
When used medically to treat disorders marked by hyperprolactinaemia (hyper secretion of prolactin), an initial dosage of 1.25 mg to 2.5 mg per day is usually recommended. This may be increased by 2.5 mg every 2-7 days until an acceptable therapeutic dosage is established. This may require taking as much as 20-30 mg per day.
When used (off-label) to support fat loss, dieting individuals commonly take between 2.5 mg and 5 mg per day. This is given in a single morning dose, due to the relatively long half-life of the drug. This may be used in short dieting cycles, and should not be considered for long-term weight management. Similar dosing schedules are common when used by athletes and bodybuilders to counter lactating gynecomastia, although higher doses may be required in some instances. A 4-6 week course of therapy, combined with a rearrangement of offending steroids, is usually undertaken.
Bromocriptine Mesylate Availability
Bromocriptine is produced in most developed countries, including the United States where it is sold as a generic drug and under the Parlodel brand name.The brand name product comes in the form of both 2.5 mg tablets and 5 mg capsules, with 100 doses per bottle. At the pharmacy, 100 5 mg capsules may cost nearly $400. In some nations, this price may be as low as $50 to 200 ($.50 to $1.00 per dose) for generic and other brands of bromocriptine. Bromocriptine is not widely diverted for sale on the black market, but can be found circulating on occasion.
Wlliam Llewellyn (2011) - Anabolics