Omnadren 250 (in its original formulation), was an oil-based injectable testosterone blend that contained four different testosterone esters: testosterone propionate (30 mg); testosterone phenylpropionate (60 mg); testosterone isocaproate (60 mg); and testosterone caproate (100 mg). Being a four-component testosterone blend, this preparation was most commonly compared to Sustanon 250. While it did contain testosterone propionate, phenylpropionate, and isocaproate in the same strengths as Sustanon, the last ester is different. It was a slightly shorter-acting drug, making Omnadren more analogous to Testoviron (the caproate ester is one carbon shorter than enanthate) than Sustanon 250. Please note that there were even older versions of Omnadren listing isohexanoate and hexanoate as the final two ingredients, which are simply different words for isocaproate and caproate.
|Brand name||Omnadren 250, Testosterone blend|
Testosterone Blend History
Omnadren 250 was developed in Poland by Polfa during the years of Soviet control. Its formulation (original) is very similar to that of Sustanon 250, barring the substitution of one of the component esters. This was likely done to avoid patent issues with the international pharmaceutical giant Organon, which exclusively controlled the global supply of Sustanon 250. In clinical medicine, Omnadren 250 was used most commonly to treat adult men suffering from low androgen levels, usually noticing symptoms of impotence or hormonal disturbance of spermatogenesis. This drug was also used on occasion to treat adolescents with delayed puberty, and women with advanced breast or endometrial cancer.
The manufacture of Omnadren 250 under the Polfa label was discontinued in 1994. That year, the newly privatized Polfa firm was renamed Jelfa, mainly to distinguish itself from other firms that use a Polfa prefix as part of their names. Jelfa continued to produce Omnadren 250 for the domestic market, which remained available without interruption in the same familiar 5-pack of ampules (albeit with a new company label and logo) for years after. Today, Jelfa continues to market Omnadren 250 in Poland, as well as in many neighboring markets including Russia, Ukraine, Kazakhstan, Uzbekistan, Kurdistan, Kyrgyzstan, Armenia, Moldavia, Latvia, Lithuania, Azerbaijan, Georgia, and Belarus, however the formulation has recently changed. All Omnadren 250 sold today carries the same exact formulation as Sustanon 250. This profile refers to the original formulation only, which is now unavailable worldwide.
How is Testosterone Blend Supplied
Omnadren 250 (original formulation) in no longer available. When manufactured, it was supplied in 1 mL glass ampules containing an oily solution; sold in boxes of 5 ampules.
Structural Characteristics of Testosterone Blend
Omnadren 250 contains a mixture of four testosterone compounds, which where modified with the addition of carboxylic acid esters (propionic, propionic phenyl ester, isocaproic, and caproic acids) at the 17-beta hydroxyl group. Esterified forms of testosterone are less polar than free testosterone, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) testosterone. Esterified forms of testosterone are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Omnadren 250 is designed to provide a rapid peak in testosterone levels (24-48 hours after injection), and maintain physiological concentrations for approximately 14 days.
Testosterone Blend Side Effects (Estrogenic)
Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.
Estrogenic side effects will occur in a dose-dependant manner, with higher doses (above normal therapeutic levels) of testosterone more likely to require the concurrent use of an antiestrogen or aromatase inhibitor. Since water retention and loss of muscle definition are common with higher doses of testosterone, this drug is usually considered a poor choice for dieting or cutting phases of training. Its moderate estrogenicity makes it more ideal for bulking phases, where the added water retention will support raw strength and muscle size, and help foster a stronger anabolic environment.
Testosterone Blend Side Effects (Androgenic)
Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependant on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.
Testosterone Blend Side Effects (Hepatotoxicity)
Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-amino-transferase, and alkaline phosphatases.
Testosterone Blend Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
Testosterone tends to have a much less dramatic impact on cardiovascular risk factors than synthetic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of testosterone to estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg per week of testosterone ester (enanthate) had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but when taken with an aromatase inhibitor a strong (25%) decrease was seen. Studies using 300 mg of testosterone ester (enanthate) per week for 20 weeks without an aromatase inhibitor demonstrated only a 13% decrease in HDL cholesterol, while at 600 mg the reduction reached 21%. The negative impact of aromatase inhibition should be taken into consideration before such drug is added to testosterone therapy.
Due to the positive influence of estrogen on serum lipids, tamoxifen citrate or clomiphene citrate are preferred to aromatase inhibitors for those concerned with cardiovascular health, as they offer a partial estrogenic effect in the liver. This allows them to potentially improve lipid profiles and offset some of the negative effects of androgens. With doses of 600 mg or less of testosterone per week, the impact on lipid profile tends to be noticeable but not dramatic, making an anti-estrogen (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week have also failed to produce statistically significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all indicating a relatively weak impact on cardiovascular risk factors. When used in moderate doses, injectable testosterone esters are usually considered to be the safest of all anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Testosterone Blend Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen, and offers strong negative feedback on endogenous testosterone production. Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Testosterone Blend Administration (General)
Testosterone propionate is often regarded as a painful injection. This is due to the very short carbon chain of the propionic acid ester, which can be irritating to tissues at the site of injection. Many sensitive individuals choose to stay away from this steroid completely, their bodies reacting with a pronounced soreness and low-grade fever that may last for a few days after each injection.
Testosterone Blend Administration (Men)
Depending on the application, the prescribing guidelines for Omnadren 250 call for a dosage of 250 mg (1 ampule) to be injected every 3 to 4 weeks. Although active in the body for a longer time, Omnadren 250 is usually administered on a weekly basis for musclebuilding purposes. This schedule will allow for the higher doses most commonly applied by athletes, and more stable elevations in hormone level. The usual dosage among male athletes is in the range of 250-750 mg per injection, taken in cycles 6 to 12 weeks in length. This level is sufficient for most users to notice exceptional gains in muscle size and strength. Some bodybuilders have been known to use excessively high dosages of this drug (1,000 mg per week or more), although this practice is generally not advised due to the higher incidence of side effects. Testosterone is ultimately very versatile, and can be combined with many other anabolic/androgenic steroids to tailor the desired effect.
Testosterone Blend Administration (Women)
Omnadren 250 is rarely used with women in clinical medicine. When applied, it is most often used to treat inoperable breast or endometrial cancer. Omnadren 250 is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature, tendency to produce virilizing side effects, and slow-acting characteristics (making blood levels difficult to control).
Testosterone Blend Availability
The original Omnadren 250 formulation is no longer available. Jelfa continues to use the trade name to market a steroid product, but it is now equivalent in makeup to Sustanon 250. See the Sustanon 250 profile for more information.
Omnadren is similar to Sustanon only in the fact that each contains four different Testosterone esters. However, they reportedly differed, both in effect and mixture. Both contain Testosterone Propionate and Testosterone Phenylpropionate. But Sustanon contains Testosterone Iscoparoate and Testosterone Decanoate, where as Omnadren contains Testosterone Isohexanoate and Testosterone Hexanoate. This gave Omnadren a distinct higher water retention rating and aromatization factor over Sustanon. (Ester type has an effect upon aromatization rates) Sustanon also remains active a few days longer than Omnadren.
Omnadren provided fast weight and strength build-up. However much of the weight gain was due to water retention from aromatization. This gave users a bloated appearance to the whole body including the face. Most users reported an increased pump, appetite, and training aggressiveness as well as elevate sex drive (duh!).
Though Omnadren remains active for 2-3 weeks, users commonly injected multiple times weekly. The noted range of dosage was quite wide as some individuals actually administered 14,000mg or more weekly. This was an unnecessary practice, though some swear it was the best way. Then again, some once thought Jim Jones made great drinks .
*From 250mg every 2 weeks to 2000-mg per day? You read that right, 2000-mg per day. A more reasonable dosage of 250-mg -1000-mg weekly was observed by most users.
As is true with one other eastern European country AAS products, Omnadren is said to be manufactured with less concern for impurities. (You should see some of this stuff under a microscope. You would swear the credo for some manufacturing was "After we pee in it we are done") For this reason, many Omnadren users experienced harsh acne (including small rash like pimples on their arms, chest, back, face, and legs). I have known a couple users who report injection site abscess problems. Surgery will most likely be needed to remove these nasty pus pockets.
So why did athletes use Omnadren? It is cheap and it worked.
Omnadren is very androgenic and anabolic. For this reason, mass and strength build-ups were high and rapid. Unfortunately, maintaining these gains post-cycle were not good. An anti-estrogen was reported as almost a must at any dosage with this product and the shut down of natural testosterone production during use was considered normal. So post-cycle use of HCG, Clomid, Novladex, and Proviron were considered almost a must as well (depending on dosage and cycle length of time). To avoid serious crashing after use, a switch to Nandrolones helped.
Anabolic Steroid Guide reference
Remark: This information was for Omnadren250 and it's old formula. Omnadren now contains the same compound as Sustanon250.
Omnadren is a four-component testosterone. The four different substances work together in such a timely manner that Omnadren remains in the body for a long time. For this reason many compare Omnadren to Sustanon 250. This comparison, however, is quite poor since, in part, there are large differences between the two compounds. Although both are "four-compo-nent testosterones" the individual substances of Omnadren and Sustanon are not completely identical. Both include testosterone phenylpropionate and testosterone propionate; however, the tes-tosterone isocaproate in Sustanon is replaced by testosterone hexanoate and the testosterone decanoate in Omnadren is replaced by testosterone hexanoate in Sustanon (see also Sustanon.)
In bodybuilding and powerlifting Omnadren is exclusively used to build up strength and mass. The term "mass buildup" can be taken quite literally by the reader since the gain is not always the way expected by its user. In most athletes Omnadren leads to quite a rapid and pronounced increase in body weight, which usually goes hand in hand with a strong water retention. This results in watery and puffy muscles. Those who take "Omna" can often be recognized by this extreme water retention. The of-ten-used term in Europe, "Omna skull," does not come from no-where but because a fast and well-visible water retention occurs also in the face which is noticeable on checks, on the front of the face, and under the eyes. Some mockingly also talk about a hydrocephalus... The pronounced androgenic component of Omnadren goes hand in hand with a high anabolic effect which manifests itself in a high strength gain characterized by a liquid accumulation in the joints, an increased pump effect, increased appetite, and a possible improved regeneration of the athlete. Since Omnadren easily aromatizes, the intake of antiestrogens is sug-gested. This can also help reduce some of the water retention. Although Omnadren has a duration effect of a good 2-3 weeks it is usually injected at least once a week.
As for the dosage there is rarely an injectable steroid with a wide spectrum such as Omnadren's. The span reaches from athletes who inject one 250 mg injection every two weeks to extremes who use eight(!) "Omnas" a day (2000 mg/day). The reason is the low price of the compound. It therefore offers an economic alternative to the expensive Sustanon, Testosterone enanthate and -propionate; that explains why some take it in these exaggerated dosages. An acceptable and, for most, sufficient dosage is 250--1000mg/week. Omnadren is often combined with Dianabol, Anadrol 50, and Deca-Durabolin which accelerates the gain in strength, mass, and water retention. The gains achieved with Omnadren, as is the case with Testosterone, for the most part, usually subside very quickly after use of the compound i~ dis-continued.
The side effects of Omnadren are similar to those of other testoster-one compounds (see Testosterone enanthate). Next to the high wa-ter retention other negative effects that are noticed are a sometimes strong acne and a distinctly increased aggressiveness in some users. An aggressive behavior can mostly be explained by the fact that athletes simply use too high a dosage of Omnadren and too low a dosage of the other (and more expensive) testosterones. The very severe acne, however, is only caused by Omnadren. Often no puru-lent pustules but many small pimples appear so that the athlete looks as if he has an allergy. This is not intended to discourage any-one but it is a fact that many athletes after a brief time develop an acne on their lower arm, upper arm, shoulder, chest, back, and also in their face which, during an earlier intake of Sustanon or Test-osterone enanthate, did not manifest itself. Women should not use Omnadren under any circumstances.
Another problem that should be considered is that possible im-purities in the injection liquid cannot be excluded since the qual-ity standards in Eastern European countries are not as high as in Western Europe and in the U.S. Thus it is possible that a 100% sterility and pureness does not exist. This could also be the rea-son for the unusually strong acne. Original Omnadren is offered by the manufacturer in a strength of 250- mg/ml ampule.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide