How Do Steroids Work?
Many people around the globe use steroids and they are very happy with the results. However, some don’t use steroids or any other type of supplements because they don’t know how they work. It is true that abusing steroids can lead to many side effects. On the other hand, using them properly can push your limits and maximize your results, while minimizing or completely avoiding side effects. So let’s find out what kind mechanism is behind these mighty substances which are gaining more and more popularity every day.
Let’s have a look at the molecular structure of steroids in general. Imagine one molecule of an anabolic/androgenic steroid (AAS) which is constantly connected to testosterone binding globulin (TeBG). Receptors are in charge of bringing both- anabolic steroids and TeBG inside of the cell. This action has as a result an increased AMP and cell metabolism. Additionally, anabolic steroid doesn’t necessarily need to be bound to anything else. It can float freely in the bloodstream until it reaches the cell. At this point it can go through the membrane and end up in the cell.
One way or another, AAS ends up inside of the cell. At this point androgen receptor (AR) starts playing its crucial role in processing and using steroids. Androgen receptor is always inside of a cell. It is a molecule significantly larger than the steroid molecule. It consists of a large number of amino acids and has the ability to be folded around the molecule of steroids. Once AAS is inside of the cell, AR gets a good grip of it and gets activated. It manages to bind the molecule of steroid very quickly and effectively.
Androgen receptors have only 2 binary modes- on and off. In fact, you can imagine it as a TV set. Once you click on the remote control, your TV is on. If you click on it again, it is off. There is no point at which the TV is somewhere between being switched on and off. This is how AR works. Once the AAS is bound to it, it is turned on and active. If there is no AAS, it will remain completely inactive and unfolded. It is also important to notice that AR will remain active for a few hours before AAS leaves. When there is no AAS to bind it will go back to its passive state, waiting for the next one to approach.
Having in mind the fact that AR will either be completely active or completely inactive, and that there are no modes in-between, we can conclude that it will be equally activated by for example, methenolone as it would be by a bound molecule from any other AAS. However, you can experience a variety of effects as a result of consuming different AAS, or different dosage, but this doesn’t happen because AR is more or less active.
When a molecule of steroid and androgen receptor are bound together, they can reach nucleus inside of the cell and create a pair with yet another activated receptor. After this pair is formed, it will bind to our DNA and particular genes, which will increase the production of mRNA. This a very important mechanism, because these genes are the ones related to the androgenic activities. In this way steroids are able to target and activate particular genes which are important for experiencing the desired effects. Additionally, some genes which are already active can have their operations enhanced, which will give better results.
It is interesting to know that mRNA will be different for different genes. It is crucial in AAS processing as it carries the valuable information cells need to create particular types of proteins. In this case, the most important proteins are Myosin and actin because muscle creation depends on these two. Production of these proteins directly depends on the production of a specific mRNA. Bear in mind that the main goal of this whole process is to create protein needed for boosting the muscles. The purpose of every steroid which enters our bloodstream is to improve the production of proteins in order to feed the muscle cells which should become bigger.
Also, one steroid together with one receptor will not result in one protein produced. This is not such an exact equation. Some pairs won’t manage to get bound to genes and DNA. Also, the amount of mRNA is not fixed. It can vary significantly. If steroid is bound to the receptor for a longer period of time, more mRNA can be produced. More mRNA will naturally result in greater quantities of the proteins in question, which can in turn result in more rapid and significant muscle growth.
Steroids are very precise in their actions. They know exactly which receptors they should target and activate. The ultimate goal of every steroid is to create the proteins needed for boosting the muscle growth. Producing these proteins happens as a result of a chain reaction in which steroid binds to the receptor which gets activated and helps steroid bind to genes. mRNA plays the crucial role in transmitting the necessary information needed for the creation of particular types of protein needed. If more mRNA is produced, it will result in more protein, and most likely in more significant muscle growth. However, you should never abuse steroids in order to make your body produce more protein. If you use them as suggested on the label, and take the correct dosage, you will see your body being transformed within months, even weeks. Bear in mind that, taking greater dosage than recommended can result in very severe side effects.