Dihydrotestosterone was first synthesized in 1935. Pfizer developed this strong androgenic steroid into an injectable medication during the mid-1950's, sold on the U.S. prescription drug market under the trade name Neodrol. This preparation contained a simple saline solution with dihydrotestosterone (50 mg/ml) in a 10 mL multi-dose vial. The product literature describes the steroid as a new androgen for the treatment of certain cases of inoperable breast cancer in females, or postoperative cases of carcinoma of the breast with metastases. It is also described as a drug effective for promoting protein anabolism in select patients. Given the unesterified nature of the drug, it was to be injected at least three times per week, although it was often required on a daily basis.
Other dihydrotestosterone preparations had also been produced over the years in other markets. Such popular brands included Pesomax (Italy), Anabolex (England, Italy), Anaboleen (England, Switzerland), and Androlone (Italy). Injectable dihydrotestosterone suspensions were ultimately short lived as prescription drug products, made effectively obsolete by newer and more effective anabolic/androgenic steroids that dominated many areas of medicine during the 1960's. Dihydrotestosterone has not disappeared completely from clinical medicine, however, and today remains available, albeit scarcely. It is currently in extremely limited use globally, mainly produced in Europe as a transdermal product for the treatment of gynecomastia and insufficient androgen levels (Andractim).
How is Neodrol Supplied
Dihydrotestosterone suspension is no longer available. When produced as Neodrol, it contained 50 mg/ml of dihydrotestosterone in saline solution, in a 10 mL multidose vial.
Structural Characteristics of Neodrol
Neodrol contained dihydrotestosterone, a primary androgenic steroid.
Neodrol Side Effects (Estrogenic)
Dihydrotestosterone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia and water retention should not be concerns even among sensitive individuals. DHT also has inherent anti-estrogenic properties, competing with other substrates for binding to the aromatase enzyme. Dihydrotestosterone may be an effective option for the treatment of gynecomastia. Studies have reported a good level of success when treating certain forms of this disorder with Andractim (transdermal dihydrotestosterone), the drug affecting the ratio of androgenic to estrogenic action in the breast area enough that a notable regression of mammary tissue has been achieved in many cases.
Neodrol Side Effects (Androgenic)
Dihydrotestosterone is the strongest natural male androgen. Higher than normal therapeutic doses are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as dihydrotestosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Note that the 5-alpha reductase enzyme does not metabolize dihydrotestosterone, so its relative androgenicity is not affected by finasteride or dutasteride.
Neodrol Side Effects (Hepatotoxicity)
Dihydrotestosterone does not have hepatotoxic effects; liver toxicity is unlikely.
Neodrol Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Therapeutic doses of dihydrotestosterone used to correct insufficient androgen production in otherwise healthy aging men are unlikely to increase atherogenic risk. Higher doses are likely to increase atherogenic risk, but less dramatically than equivalent doses of synthetic oral anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Neodrol Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Neodrol Administration (Men)
Early prescribing information for Neodrol recommended an injection of 50 mg given three to seven times per week, for the promotion of protein anabolism. For physique- or performance-enhancing purposes, similar doses are used, but generally on the higher end of the therapeutic spectrum (50 mg daily). Dihydrotestosterone is of little value for building muscle, and is most commonly applied for cutting or pure-strength-promoting purposes.
Neodrol Administration (Women)
Early prescribing information for Neodrol recommended an injection of 100 mg given three to seven times per week, for the treatment of breast cancer. Dihydrotestosterone is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.
Dihydrotestosterone suspension (Neodrol) is no longer manufactured, and is presently unavailable on the black market.
Newbies Research Guide reference
This is a parent compound of a number of steroid reparations. The hormone itself is one, which occurs naturally in the body. DHT is responsible for several of the androgenic effects of testosterone like facial hair, genetic balding, and male reproductive organ development. It plays a major role in the building of skele- tal muscles. A great percentage of endogenous and exogenous testosterone’s are converted to DHT in the system which many feel results in the actual anabolism of muscle tissue. Common side effects of DHT are acne and accelerated balding.
Wlliam Llewellyn (2017) - Anabolics
Newbies Research Guide