Sibutramine Hydrochloride History
Sibutramine hydrochloride received Food and Drug Administration approval for sale as a prescription weight-loss agent in 1998. It was developed and marketed by Abbott Laboratories, which sold the drug on the U.S. market under the brand name Meridia. The company also sold the drug in many international markets under the name Reductil. Sibutramine enjoyed only a limited period of sales in the U.S., as it was removed from the market in October 2010 under FDA pressure, citing an increased incidence of adverse cardiovascular events. Abbott has since also withdrawn sibutramine from many markets worldwide. Note that sibutramine remains classified as a schedule IV controlled substance in the United States.
How is Sibutramine Hydrochloride Supplied
Sibutramine hydrochloride is most commonly supplied in capsules of 5 mg, 10 mg, and 15 mg.
Structural Characteristics of Sibutramine Hydrochloride
Sibutramine hydrochloride is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamine. It is chemically a racemic mixture of (+) and (-) enantiomers of 1-(4-chlorophenyl)-N,N-dimethyl-a-(2- methylpropyl)- cyclobutanemethanamine.
Sibutramine Hydrochloride Side Effects
The most common side effect with sibutramine is an increase in blood pressure, a trait that contraindicates its use in patents with high blood pressure or other cardiovascular issues. Other common side effects include dry mouth, sleeplessness, irritability, back pain, stomach upset, and constipation, all of which tend to become reduced in magnitude as the user becomes accustomed to the drug. Sibutramine hydrochloride should be discontinued immediately if any of the more serious side effects or symptoms of toxicity occur, including excitement, restlessness, loss of consciousness, confusion, agitation, weakness, shivering, clumsiness, rapid heartbeat, large pupils, vomiting, difficulty breathing, chest pains, swelling of feet, ankles or legs, fainting, disorientation, depression, high fever, eye pain, tremor, or excessive sweating. Note that increased incidence of cardiovascular events has prompted the removal of this product from most markets. It is no longer considered a safe product by many standards.
Sibutramine Hydrochloride Administration
Sibutramine hydrochloride is used for the management of obesity, including weight loss and maintenance, and should be used in conjunction with a reduced-calorie diet. This drug has been used with patients who have additional weight-related risk factors including controlled hypertension, diabetes, and dyslipidemia (high cholesterol). The recommended starting dosage for most patients is 10 mg once daily, which is to be adjusted upwards to 15 mg after 4 weeks if weight loss has not been sufficiently initiated. Higher doses are usually not recommended.
Sibutramine Hydrochloride Availability
This drug is subject to limited availability following an FDA supported recall in the United States, and subsequently its removal from many other international markets for safety reasons.
Wlliam Llewellyn (2011) - Anabolics