Drostanolone propionate is an injectable anabolic steroid derived from dihydrotestosterone (DHT). Here, the DHT backbone has been modified with a 2-methyl group to increase its anabolic properties, making this agent significantly more effective at promoting the growth of muscle tissue than its non-methylated parent. Drostanolone propionate is described in product literature as a “steroid with powerful anabolic and anti-estrogenic properties,” and indeed does seem to share some of both properties. Admittedly, however, its anabolic properties are more properly described as moderate, especially when placed in the context of other agents. The drug is most often used by dieting bodybuilders and athletes in speed sports, where it is highly favored for its ability to produce solid increases in lean muscle mass and strength, which are usually accompanied by reductions in body fat level and minimal side effects.
|Brand name||Masteron, Drostanolone propionate, Drolban, Masteril, Metormon, Permastril, Mastisol, Masterid|
|Progestational Activity||no data available (low)|
Drostanolone Propionate History
Drostanolone propionate was first described in 1959. Syntex developed the agent alongside such other well-known steroids as Anadrol and methyldrostanolone (Superdrol), also first described in the same paper. Drostanolone propionate would be introduced as a prescription drug product approximately a decade later. Lilly had an agreement with Syntex to split certain research and development costs in exchange for the rights to market the results of that research. Lilly would, therefore, sell drostanolone propionate in the U.S. under the Drolban brand name, while Syntex would sell/license it in other markets. Products included Masteron in Belgium (Sarva-Syntex) and Portugal (Cilag), Masteril in the U.K. and Bulgaria, and Metormon in Spain. Drostanolone propionate was also found in such popular preparations as Permastril (Cassenne, France), Mastisol (Shionogi, Japan), and Masterid (Grunenthal, Germany Democratic Republic).
The U.S. Food and Drug Administration approved drostanolone propionate for the treatment of advanced inoperable breast cancer in postmenopausal women. This remained the principle clinical indication for the agent in all international markets as well. The prescribing literature reminds doctors and female patients that there is considerably less virilization with drostanolone propionate as compared to equal doses of testosterone propionate, suggesting this was a much more comfortable alternative to testosterone injections for the given audience. Still, the given dosage level (300 mg per week) was relatively high, and the literature also reminds us that mild virilization symptoms still commonly occur, such as deepening of the voice, acne, facial hair growth, and enlargement of the clitoris. It also reports that marked virilization sometimes follows long-term therapy.
While highly popular among athletes during the 1970’s and ’80’s, drostanolone propionate ultimately enjoyed limited success as a prescription agent. Manufacturers began voluntarily discontinuing sale of the agent in various markets before long, likely due to the advent of more effective therapies for breast cancer, as well as the slow decline in steroid prescriptions for this phase of treatment. One of the first preparations to go was the U.S. Drolban, which was removed from market during the late 1980’s. Permastril and Metormon were soon dropped as well. The last remaining Western preparation containing drostanolone propionate was Masteron from Belgium, which disappeared by the late 1990’s. Drostanolone propionate remains listed on the U.S. Pharmacopias, suggesting there is presently no legal roadblock to its sale, although its reemergence as a prescription drug product seems highly unlikely.
How is Drostanolone Propionate Supplied
Drostanolone propionate is no longer available as a prescription drug preparation. When produced, it was supplied in the form of 1 mL and 2 mL ampules and 10 mL vials containing 50 mg/ml or 100 mg/ml of steroid in oil.
Structural Characteristics of Drostanolone Propionate
Drostanolone (also known as dromostanolone) is a modified form of dihydrotestosterone. It differs by the introduction of a methyl group at carbon-2 (alpha), which considerably increases the anabolic strength of the steroid by heightening its resistance to metabolism by the 3-hydroxysteroid dehydrogenase enzyme in skeletal muscle tissue. Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) drostanolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. The halflife of drostanolone propionate is approximately two days after injection.
Drostanolone Propionate Side Effects (Estrogenic)
Drostanolone is not aromatized by the body, and is not measurably estrogenic. An antiestrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, drostanolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention.This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. As a non-aromatizable DHT derivative, drostanolone may impart an anti-estrogenic effect, the drug competing with other (aromatizable) substrates for binding to the aromatase enzyme.
Drostanolone Propionate Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher than normal therapeutic doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone is a steroid with relatively low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. Note that drostanolone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride.
Drostanolone Propionate Side Effects (Hepatotoxicity)
Drostanolone is not c17-alpha alkylated, and not known to have hepatotoxic properties. Liver toxicity is unlikely.
Drostanolone Propionate Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Drostanolone should have a stronger negative effect on the hepatic management of cholesterol than testosterone or nandrolone due to its non-aromatizable nature, but a weaker impact than c-17 alpha alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Drostanolone Propionate Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Drostanolone Propionate Administration (Men)
Drostanolone propionate was not FDA approved for use in men. Prescribing guidelines are unavailable. For physique- or performance-enhancing purposes, this drug is usually injected three times per week. The total weekly dosage is typically 200-400 mg, which is taken for 6-12 weeks. This level of use is sufficient to provide measurable gains in lean muscle mass and strength.
Drostanolone propionate is often combined with other steroids for an enhanced effect. Common stacks include an injectable anabolic such as Deca-Durabolin® (nandrolone decanoate) or Equipoise® (boldenone undecylenate), which can provide notably enhanced muscle gains without excessive water retention. For mass gains, it is often combined with an injectable testosterone. The result here can be solid muscle gain, with a lower level of water retention and other estrogenic side effects than if these steroids were used alone (usually in higher doses). Masteron, however, is most commonly applied during cutting phases of training. Here it is often combined with other non-aromatizable steroids such as Winstrol®, Primobolan®, Parabolan, or Anavar, which can greatly aid muscle retention and fat loss, during a period which can be very catabolic without steroids.
Drostanolone Propionate Administration (Women)
The prescribing guidelines for Drolban recommended a dose of 100 mg given three times per week. Therapy is given for a minimum of 8 to 12 weeks before an evaluation of its efficacy is made. If successful, the drug may be continued for as long as satisfactory results are obtained. Note that virilization symptoms were common at the recommended dosage. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week is most common, taken for 4 to 6 weeks. Virilization symptoms are rare in doses of 100 mg per week or below. Note that due to the short-acting nature of the propionate ester, the total weekly dosage is usually subdivided into smaller injections given once every second or third day.
Drostanolone Propionate Availability
Drostanolone propionate is presently unavailable as a prescription drug product. All supplies of this drug come from export companies or underground steroid manufacturers.
Drostanolone Propionate is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
Magnus Pharmaceuticals makes the product Drostanolone 100 primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
Masteron is a highly androgenic injectable steroid that is a synthetic derivative of DHT (dihydrotestosterone). Since DHT does not aromatize to estrogens, there was no noted water retention during administration. If a bodybuilder had achieved a low body fat level, this drug was reported to dramatically improved shape and hardness in muscle tissue while augmenting the vascular appearance of a contest ready athlete. Normally, Masteron was used only during the last 3-5 weeks before a show as part of a pre-contest stack. In this case, 100-mg was commonly injected every second or third day (2-3 times weekly) by males and at a dosage of 50mg every other day by most women whom reported use. Additionally, according to available literature, Masteron is quite anticatabolic and anti-estrogenic in nature due to receptor inhibition. So the reported characteristics of this drug do have supportive clinical validation to consider.
Combined with so- called mass steroids, Masteron did aid in a rapid build-up of strength and mass even with its relatively moderate anabolic qualities. However, Masteron was not reported to be the best choice for this purpose by those polled. DHT can promote hair loss and prostate disorders in prone individuals though it is not well documented as to whether or not deviants of the DHT structure can in all case do the same.
Masteron has a receptor binding ability 3-5 times greater than that of testosterone. This means that the drug can hang out longer in androgen receptor-sites and is not easily displaced. The result should be increased AAS activity.
An interesting facet of Masteron is the way it acts as an anti-estrogen. This is due to its ability to compete for the aromatase receptor. As the reader is aware of by now, many AAS are capable of conversion to estrogens. The process is caused by an enzyme called aromatase. (Of course the process of AAS conversion to estrogen is referred to as aromatization) If a drug has the ability to inhibit the enzyme at its own receptor and still act as a powerful non-aromatizing AAS, its interesting and unusual to me.
My personal experiences with this drug have always been favorable with no negative side effects. Additionally I feel that the drug has had value as a sort of AAS moderator. Let me explain this. Masteron has a high SHBG and albumin binding rate. Since these two hormone binding proteins prevent AAS from merging with their receptors, some would assume this is a bad thing. Masteron is 3-5 times more active than testosterone, so the unbound portion circulating in the blood stream goes a long way. Since the drug binds a higher percentage of SHBG and albumin, any other AAS co-administered with it remains in an unbound/active/free state to a greater extent and is able to induce a greater response. This is an example of noted drug synergy common to protocols reported as most effective yet requiring lower dosages to accomplish a specific result. The implication is that lower dosages of co-administered drugs allowed a decrease in negative side effects.
A point of interest is that two OTC prohormones in the United States have similar effects to Masteron (though oral administration is not the most effective delivery method and injection type administration would be illegal in most countries) (1) 5a-androst-1-en- 3b,17b- dione (2) 5a-androst-en-3b,17b-diol. My personal research has shown that there is a realistic approach to an orally administered version of the latter of the two drugs that has shown great promise. We will complete the final testing soon before turning the project over to the crazies at Hazardous Materials Supplements. Personally, I am totally stoked about the project due to its vast application potential in the world OTC supplemental industry. The key is a compound from Eastman that allows lipophilic substances to become hydrophilic (Oil soluble to water soluble). This means that the high expense of effective supplements like methoxyisoflavone (and its deviants) to be reduced due to lower dosage requirements.
Since this drug clears the body quickly, it was a favorite for tested competitors.
Anabolic Steroid Guide reference
Masteron is a steroid highly valued by competing bodybuilders. The great popularity of this injectable steroid in bodybuilder circles is due to the extraordinary characteristics of its included substance. Drostanolone propionate is a synthetic derivative of dihydrotestosterone. This causes the Masteron not to aromatize in any dosage and thus, it cannot be converted into estrogens. Since Masteron is a predominantly androgenic steroid, the athlete can increase his androgen level without also risking an increase in his estrogen level. This results in a dramatically improved hardness and sharpness of the muscles. One must, however, make a distinction here since Masteron does not automatically improve the quality of muscles in everyone. A prerequisite is that the athlete's fat content must already be very low. In this case Masteron can then be the decisive factor between a smooth, flat muscle or a hard and ripped look. For this purpose Masteron is often only used during the last four weeks before a competition so that the muscles get the last "kick." Masteron is especially effective in combination with steroids such as Winstrol, Parabolan, Primobolan, Oxandrolone and also Testosterone propionate.
The usual dosage taken by athletes is around 100 mg three limes per week. Since the substance drostanolone propionate is quickly broken down in the body, frequent and regular injections are necessary. This fact makes Masteron a very interesting steroid when dop-ing tests must be passed by a negative urine analysis. Since the propionate substance of drostanolone does not remain in the body very long in a sufficient, detectable amount, athletes inject the compound with great success up to two weeks before a test. However, since it also has anabolic characteristics and thus helps the buildup of a high-qualitative muscle system, the use of Masteron is not only limited to the preparation stage for a competition. Athletes who want to avoid water retention and who readily have a problem with an elevated estrogen level, likewise appreciate Masteron. Also in this case usually one ampule (100 mg) is injected every second day. In combination with Primobolan, Winstrol or Testosterone propionate no enormous strength and weight gains can be obtained, only high-quality and long-lasting results. Although women do not use Masteron very often some national and international com-peting female athletes do take it before a championship. The dosages observed are normally 100 mg every 4-5 days.
Masteron is not hepatoxic so liver damage is quite unlikely. High blood pressure and gynecomastia are not a problem since neither water nor salt retention occurs and the estrogen level remains low. The main problem are acne and a possible accelerated hair loss since dihydrotestosterone is highly affinitive to the skin's androgen receptors, in particular, to those on the scalp. Since Masteron, in most cases, is not administered in excessively high dosages and the in-take, at the same time, is limited to a few weeks, the compatibility for the athlete is usually very good. The Masteron package with two ampules costs between $30 and $40 on the black market.
Newbies Research Guide reference
Masteron, or drostanolone propionate, is a popular steroid among competitive bodybuilders. It is commonly used in contest preparation for many reasons. To begin with, drostanolone propionate is a derivative of DHT(dihydrotestosterone), and therefore, it will not aromatize into estrogen. Competing bodybuilders find this extremely beneficial because aromatization typically causes excess water retention which may give the muscles a smooth appearance. Another advantage of Masteron is its strong androgenic component. The androgenic effect of this steroid can cause a noticeable improvement in muscle density and hardness which can help the bodybuilder obtain the “ripped” look if his bodyfat percentage is low enough. The androgenic effect is also crucial because it helps to provide sufficent “kick” or “drive” for intense training when an athlete has lowered his caloric intake for contest preparation. Masteron can also be used successfully by bodybuilders preparing for a drug-tested show. The substance drostanolone propionate is fast acting and quickly broken down. The athlete can therefore use Masteron up to about ten days before a drug test. The average dosage of Masteron is 100 mg injected every other day. It is best to inject Masteron every 2-3 days because it has a short duration of effect. Popular steroids stacked with Masteron include Parabolan(trenbolone hexahydrobencylcarbonate), Winstrol(stanozolol), and oxandrolone. Athletes rarely experience any side effects with this steroid. Masteron is not hepatoxic, and gynecomastia should not be a concern since it does not convert into estrogen. Some possible side effects include acne, accelerated hair loss, and increased aggression. The main disadvantage of Masteron is its very poor availability on the black market and its high price. Masteron from Belgium comes in a box of two ampoules. Each 2 ml amp will contain 100 mg of drostanolone propionate. One of these boxes containing two amps can cost well over $50 on the black market.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide