Chlorodehydromethylandrostenediol (CDMA) is an oral anabolic steroid derived from testosterone. It is extremely close in structure to chlorodehydromethyltestosterone (Oral Turinabol), differing only by the substitution of the basic steroid 3-keto group with a 3-hydroxyl. It is essentially a "diol" form of Oral Turinabol, and with this understanding is often described as a "prohormone" or "prosteroid"to this well-known and highly valued anabolic steroid. While some conversion to active chlorodehydromethyltestosterone is assumed, based on its structure it is likely that this conversion is far from complete, and that much of the anabolic and androgenic activity received with use is intrinsic to CDMA. This steroid is non-aromatizable, and exhibits a greater tendency for anabolic as compared to androgenic effect.
|Brand name||Halodrol, Chlorodehydromethylandrostenediol|
|Androgenic||no data available|
|Anabolic||no data available|
|Progestational Activity||no data available (low)|
Chlorodehydromethylandrostenediol was first described in 2005, when it was introduced to the U.S. supplement market as a "prosteroid" by Gaspari Nutrition. The agent was considered a "grey market" product, containing a drug that was not technically illegal due to it not being specifically listed in previous controlled substance laws. The designation of nutritional supplement, however, was viewed as highly controversial. In November 2005, Halodrol was the subject of a scathing article in the Washington Post for its unrestricted and likely illegal OTC sale. Don Catlin of the UCLA Olympic Analytical Laboratory analyzed the product for the Post, and described Halodrol as containing, "a steroid that closely resembles Oral-Turinabol, the principal steroid used to fuel East Germany's secret, systematic sports doping program." Catlin also claimed that the product contained desoxymethytestosterone (Madol), something the manufacturer has denied.
Although no specific action was taken on the part of the FDA concerning chlorodehydromethylandrostenediol, the manufacturer voluntarily discontinued its sale in mid-2006, likely fearing government sanctions if it continued to manufacture the agent indefinitely. During its brief period of time, Halodrol was an extremely well-selling item, and by some estimates was the single best selling hormonal product ever sold over the counter in the U.S., with total sales estimated to be in the tens of millions of dollars. Today, the original Halodrol-50 product from Gaspari is no longer manufactured, and few companies will market the active drug for fear of FDA scrutiny. In September 2006, Gaspari introduced a replacement formula for Halodrol called Halodrol Liquigels, which includes arachidonic acid (profiled in this book), an aromatase inhibitor, and several other ingredients to impart an anabolic effect.
How is Halodrol Supplied
Chlorodehydromethylandrostenediol is not available as a prescription drug product. When manufactured as a supplement, it contained 50 mg of steroid per tablet.
Structural Characteristics of Halodrol
Chlorodehydromethylandrostenediol is a modified form of testosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration^) the introduction of a double bond between carbons 1 and 2 (1-ene), which shifts the anabolic to androgenic ratio in favor of the former, 3) the attachment of a chloro group at carbon 4, which inhibits steroid aromatization and reduces relative androgenicity, and 4) the substitution of 3-keto with 3-hydroxyl, which reduces relative steroid activity.
Halodrol Side Effects (Estrogenic)
Chlorodehydromethylandrostenediol is not aromatized by the body, and is not measurably estrogenic. An antiestrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.
Halodrol Side Effects (Androgenic)
Although chlorodehydromethylandrostenediol is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. For those with a genetic predisposition, anabolic/androgenic steroids may aIso aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, body and facial hair growth, and clitoral enlargement. Note that chlorodehydromethylandrostenediol is not extensively metabolized by the 5-alpha reductase enzyme, so its relative androgenici.ty is not greatly altered by the concurrent use of finasteride or dutasteride.
Halodrol Side Effects (Hepatotoxicity)
Chlorodehydromethylandrostenediol is a cl 7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of cl 7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain.
Halodrol Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values, and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Chlorodehydromethylandrostenediol has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Halodrol Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Halodrol Administration (General)
Prescribing guidelines generally advise that oral steroids can be taken with or without meals. The difference in bioavailability is generally not regarded as substantial. However, a 2016 study on newborn infants did find the absorption of oxandrolone to be significantly improved when dissolved directly in fat (MCT oil). If the diet includes considerable fat content, taking this oral steroid with meals might be more advantageous.
Halodrol Administration (Men)
Chlorodehydromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. When used for physique or performance enhancing purposes, an effective oral daily dosage falls in the range of 50-100 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for noticeable increases in lean muscle mass and strength. Higher doses will impart a stronger effect, but are also more likely to present significant hepatotoxicity.
Halodrol Administration (Women)
Chlorodehydromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. Chlorodehydromethylandrostenediol is generally not recommended for women for physique- or performance-enhancing purposes due to its high per-tablet dosage and the possibility of virilizing side effects. Low doses (12.5 mg per day or less) are unlikely to produce virilizing side effects, provided it was used for brief periods of 4-6 weeks. Note that as with all anabolic/androgenic steroids, the chance for virilization cannot be completely excluded.
Chlorodehydromethylandrostenediol was never made available as a prescription drug product. This compound is available as an underground/designer steroid only.
Wlliam Llewellyn (2017) - Anabolics