Glucophage & Glucophage-XR

Glucophage is an antidiabetic drug prescribed to treat Type II diabetes. Type II diabetes is also called non-insulin-dependent diabetes mellitus. Individuals who have Type II diabetes are usually unable to produce enough insulin naturally (in response to the food they ingest) or suffer cell insulin receptor-site insensitivity.

Brand name Glucophage, Glucophage-XR

However, Glucophage can be prescribed by a doctor for Type I diabetics as a means of additional glucose (blood sugar) control in unison with insulin injections.

Clinical use of Glucophage for diabetics is fairly common. What the drug does is:

  1. Increase cell insulin receptor-site number and sensitivity.
  2. Decreases the amount of glucose/sugar the intestines absorb.
  3. Decrease the amount of glucose/sugar the liver manufactures. (One source of liver glucose production is amino acids/protein).

These three effects explain why clinical administration of Glucophage seldom results in reports of added hypoglycemic effects during administration of the drug alone. However, when combined with insulin injections and/or sulfonylureas (Glipizide) a significant increase in carbohydrate requirements and weight gain is realized.

Polled bodybuilders utilized the effects of Glucophage differently for different phases;

1. During mass gain phases utilizing exogenous insulin, 500-850 MG 1-2 times daily of Glucophage increased the effective value of insulin. This was due to an elevation in receptor-site number and sensitivity. Glucophage also decreased the amount of insulin needed for maximum results.

2. During pancreatic regeneration or protocols that included Glipizide, Glyburide, or other pancreatic/insulin stimulation, Glucophage increased the effectiveness and amplified results. 500 MG 2 x daily was the common Glucophage dosage for this purpose.

3. During diet phases, bodybuilders have utilized Glucophage as a means of decreasing glucose production by the liver and glucose absorption by the intestines. This in itself decreases insulin secretion by the pancreas and increases the body's dependence upon fat stores for energy requirements. This was employed especially so during GH and PGF-2 use, and was synergistic with anabolic/androgenic steroids. SINCE cell insulin receptorsites are more sensitive and since there is an existing cross-over stimulation between IGF-1 and Insulin (and their opposing receptor-sites) lean mass retention was notably increased. This effect helped decrease the negative effects dieting has upon IGF-1 production endogenously.

*Since less IGF-1 is produced during diet phases, less lean mass is normally retained. If cell receptor-sites are more plentiful and sensitive, less IGF-1 is required for stimulation. 500MG daily of Glucophage was usually considered effective for this.

Glucophage was taken with meals and never less than 6 hours before sleeping. Individuals with kidney problems did not take Glucophage and most athletes were aware of the fact that in some cases stacking with oral 17-alfa-alkylated drugs could induce even greater liver damage.

The drug insert gives some insight into the potential dangers of non-monitored use:

Combining Glucophage with Digoxin (Lanoxin), furosemide (Lasix), or any diuretic is dangerous for individuals with heart problems. Glucophage has also been known to encourage lactic acidosis. Lactic acidosis is a build-up of lactic acid in the blood stream. Prolonged excessive lactic acid build-up in blood can cause serious damage. Alcohol use increases the risk of lactic acidosis during periods of Glucophage use. A doctor should be consulted for monitoring prior to use.


**Dizzy or lightheaded.
** Slow or irregular heart beat.
**Feeling very tired, weak, or uncomfortable.
**Feeling cold.
**Unusual muscular pains.
**Unusual stomach discomfort.

Newbies Research Guide reference

Known Name Brands: Glucophage, Mellitron. Glucophage - 850 mg. tablets - 40 per box. Glucophage is a brand name for metformin which is an oral hypoglycemic drug. Glucophage was made to be used to control adult onset diabetes. This drug is will increase the body’s ability to transport glucose into the muscle cells much better by increasing insulin sensitivity. This substance will also inhibit the body’s formation of sugar by the liver whereby lowering insulin secretion in the body. This substance is very similar to phenformin that is also an oral hypoglycemic except that phenformin is considered the harsher of the two com- pounds. Phenformin is considered to be from 5 - 10 times stronger than Glucophage at what it does for the body on a mg. per mg. comparison. Glucophage has signifigantly less side effects than phenformin has as well. The chance for an overdose causing hypoglycemia with the use of Glucophage is dose related whereas you almost have to take a lethal dose. It is common knowledge that Glucophage will increase insulin sensitivity as well. As far as bodybuilders are concerned, this product is used as an oral form of insulin. It will cause greater glycogen supercompensation during carb-ups as well as lowering blood glucose for those that are using the BodyOpus or Atkins diet to induce ketosis more easily.

Common side effects of Glucophage are a metallic taste in the mouth, nausea, and vomiting. This will become on the next big drugs used by professional body- builders in the coming years for its ability as a repartitioning agent and blood glucose disposal agent.

Effective Dose: 1,700 mg. per day in divided doses.You have to take this with meals and with water to avoid stomach upset.


L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Newbies Research Guide

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