Nandrolone phenylpropionate is an injectable form of the anabolic steroid nandrolone. The properties of this drug are strikingly similar to those of Deca-Durabolin, which uses the slower acting drug nandrolone decanoate. The primary difference between these two preparations is the speed in which nandrolone is released into the blood. While nandrolone decanoate provides a release of nandrolone from the area of injection lasting approximately 3 weeks, nandrolone phenylpropionate is active for only about a week. In clinical situations, Deca-Durabolin can thus be injected once every 2 or 3 weeks, while Durabolin is usually administered every several days to once weekly. Otherwise, the two drugs are virtually interchangeable. Like Deca-Durabolin, Durabolin is valued by athletes and bodybuilders for its abilities to promote strength and lean muscle mass gains without significant estrogenic or androgenic side effects.
|Brand name||Durabolin, Nandrolone phenylpropionate, Superanabolon|
Nandrolone Phenylpropionate History
Nandrolone phenylpropionate was first described in 1957. It became a prescription medication shortly after, sold by the international pharmaceuticals giant Organon (now Merck/MSD) under the brand name Durabolin. When first introduced to the United States, indicated uses of nandrolone phenylpropionate included pre- and postoperative lean mass retention, osteoporosis, advanced breast cancer, weight loss due to convalescence or disease, geriatric states (general weakness and frailty), burns, severe trauma, ulcers, adjunct therapy with certain forms of anemia, and selective cases of growth and development retardation in children. During the 1970’s, the FDA began revising the indicated uses of this drug, however, and they were soon significantly narrowed. Moving forward, the drug was mainly being indicated for the treatment of advanced metastatic breast cancer, and as adjunct therapy for the treatment of senile and post-menopausal osteoporosis.
Durabolin was a key focus of Organon’s marketing efforts only for well less than a decade following its release. Once Deca-Durabolin was introduced during the 1960’s, this shorteracting counterpart, although still available, started to take a back seat. Durabolin was not completely abandoned by Organon at the time, however, partly due to the fact that it was given a slightly different set of therapeutic uses in certain countries, and therefore continued to hold onto a niche market for some time. As the size of the anabolic steroid market continued to grow throughout the 1970’s and ’80’s, it was nandrolone decanoate that was attracting the most attention of other drug manufacturers. Numerous drug companies had produced their own versions of nandrolone phenylpropionate over the years, however. Today, the drug remains scarcely available. It is unknown if the present owner of Organon (Merck/MSD) will market Durabolin, or if its production (as a brand name product) has ended.
How is Nandrolone Phenylpropionate Supplied
Nandrolone phenylpropionate is available in select human drug markets. Composition and dosage may vary by country and manufacturer, but usually contain 25 mg/mL or 50 mg/mL of steroid dissolved in oil.
Structural Characteristics of Nandrolone Phenylpropionate
Nandrolone phenylpropionate is a modified form of nandrolone, where a carboxylic acid ester (propionic phenyl ester) has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Nandrolone phenylpropionate provides a sharp spike in nandrolone release 24-48 hours following deep intramuscular injection, and declines to near baseline levels within a week.
Nandrolone Phenylpropionate Side Effects (Estrogenic)
Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Consequently, estrogen- related side effects are a much lower concern with this drug than with testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.
It is of note that nandrolone has some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. The side effects associated with progesterone are similar to those of estrogen, well. The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.
Nandrolone Phenylpropionate Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen.
Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN).
The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.
Nandrolone Phenylpropionate Side Effects (Hepatotoxicity)
Nandrolone is not c-17 alpha alkylated, and not known to have hepatotoxic effects. Liver toxicity is unlikely.
Nandrolone Phenylpropionate Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels. This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate. Nandrolone should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Nandrolone Phenylpropionate Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100 mg expected to suppress endogenous testosterone production. Studies administering 100 mg injection of nandrolone phenylpropionate demonstrated a rapid suppression of serum testosterone following a single injection. Testosterone levels declined to approximately 30% of initial level by day 3 after drug administration, and stayed suppressed for approximately 13 days. Regular use is expected to significantly lengthen the endogenous hormone recovery window. It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked in spite of a low tendency for estrogen conversion. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Nandrolone Phenylpropionate Administration (Men)
For general anabolic effects, early prescribing guidelines recommend a dosage of 25-50 mg per week for 12 weeks.
The usual dosage for physique- or performance-enhancing purposes is in the range of 200-400 mg per week, taken in cycles 8 to 12 weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength. Note that due to the fastacting nature of the phenylpropionate ester, the weekly dosage is usually subdivided into 2 separate applications spaced evenly apart.
Nandrolone Phenylpropionate Administration (Women)
For general anabolic effects, early prescribing guidelines recommend a dosage of 25-50 mg per week for 12 weeks.
When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week (given in a single weekly injection) is most common, taken for cycle lasting 4 to 6 weeks. Higher doses or longer durations of use are discouraged due to potential for androgenic side effects. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should virilizing side effects become a concern, nandrolone phenylpropionate should be discontinued immediately to help prevent a permanent appearance.
Nandrolone Phenylpropionate Availability
Nandrolone phenylpropionate has declined extensively as a pharmaceutical product. Given its short action, and the limited use of its longer-acting cousin nandrolone decanoate in clinical medicine, there are very few (if any) unique applications remaining for this drug. Thus, there is little justification for its continued production.
Brand name Durabolin appears to be unavailable in all markets worldwide.
A small number of generic and brand name products remain in less regulated markets (mainly in Asia), due to continued demand by athletes and bodybuilders.
Superanabolon from Spofa in the Czech Republic is also still in manufacture. It contains only 25 mg of steroid per 1 mL ampule, which makes it in relatively low demand among athletes.
Iran Hormone (Iran) makes a 25 mg/mL generic nandrolone phenylpropionate in 1 mL ampules. Counterfeits are not known to be a problem.
Nandrolone Phenylpropionate is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
Magnus Pharmaceuticals makes the product Nandro F primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
Durabolin is a fast acting nandrolone with an active-life of 2-3 days as compared to Deca Durabolin's 14-16 day active-life. For this reason, males injected Durabolin every 2-3 days and women reportedly avoided virilization effects with injections every 5- 7 days (while still enjoying a very high quality but slow lean mass gain). For more rapid strength and mass gains, Deca Durabolin was noted as a better choice of nandrolone. Post-cycle retention of lean muscle mass gains were somewhat better with Durabolin however. This was mostly due to the fact that most individuals used lower dosages of Durabolin and therefore experience less HPTA suppression. Durabolin is highly anabolic, which means a quick build-up of proteins stored intracellularly in muscle tissue, and a positive nitrogen balance. For this reason, as with all nandrolones, a high protein diet was a must. Since Durabolin caused much less water retention than Deca Durabolin (again due to lower dosages), it was an excellent addition to pre-contest stacks. Also due to a shorter active-life, Durabolin appears to aromatize less than Deca.
This drug has no reported negative effect on the liver but will decrease natural androgen production in higher long-term dosages. Durbolin was considered the safest AAS. I have utilized Durabolin's fast acting highly anabolic qualities as part of a site-injection protocol (stacked with testosterone propionate and Primobolan Depot with methandriol deipropionate) with great results.
Anabolic Steroid Guide reference
Durabolin is very similar to the popular Deca-Durabolin. Durabolin must be injected frequently and in regular inter-vals. The substance nandrolone-phenylpropionate quickly gets into the blood, where it remains active for two to three days. Athletes who hope for optimal results inject Durabolin every third day, or even every two days. The dosage is around 50-100 mg per injec-tion, or a total of 150-300 mg/week. Those who have access to the 50 mg version should take advantage of it since it is less expensive than the 25 mg version, which is normally more easily available. in addition, the 1-2 ml injections are more pleasant than the 2-4 ml. Durabolin has a distinct anabolic effect which assists the protein synthesis and allows the protein to be stored in the muscle cell in large amounts. This is combined with a moderate androgenic com-ponent which stimulates the athlete's regeneration and helps main-tain the muscle mass during a diet. It shows that Durabolin stores much less water in the body than Deca-Durabolin. For this reason, Durabolin is more suitable for a preparation for a competition while Deca should be given preference for the buildup of strength and muscle mass. Durabolin, however, can be used for this purpose as well. The gains are fewer and slower than with Deca but of a higher quality and remain, for the most part, after discontinuing the com-pound. A stack 34 suitable for this purpose would be, e.g. 56 mg Durabolin every 2 days, 50 mg Testosterone propionate every days, and 20 mg Winstrol tablets every day.
The side effects of Durabolin are few. Water retention, high blood pressure, an el-evated estrogen level, and virilization symptoms occur less often with Durabolin than with Deca-Durabolin. Female athletes therefore take Durabolin in weekly intervals since, due to its short duration of effect, no undesirable concentration of androgen takes place. They achieve good results with 50 mg Durabolin/week, 50 mg Testosterone propionate every 8 -10 days, and 8-10 mg Winstrol/day, or 10 mg Oxandrolone/day. Three to four day intervals between the relative injections are to be observed. Durabolin is one of the safest non-toxic steroids offering satisfactory results. Durabolin has no negative effect on the liver function so it can even be taken in cases of liver disease. Side effects occur only in rare cases and in persons who are extremely sensitive. Virilization symptoms in women such as huskiness, deep voice, hirsutism, acne, and increased libido are possible but occur only rarely if reasonable dosages are taken at reasonable intervals. Men usually experience no symptoms with Durabolin. Since the release of gonadotropins in the hypophysis is inhibited, there is a chance that the body's own testosterone production in a male athlete will be lower when the compound is taken over a prolonged time and in excessive doses.
The main disadvantages of Durabolin, for most athletes, consist of its poor availability on the black market, the fact that frequent in-jections are needed, and the high cost, three ampules of 25 mg each, costs approx. $24-36- on the black market. American Durabolin is available in 25 mg/ml, 5 ml vials, and 50 mg/ml in 2 vials.
Newbies Research Guide reference
50 mg/cc, 2 cc/vial. This steroid is almost identical to Deca-Durabolin except that is a faster acting compound. Its gets into the system rapidly and is active for less than a week. Therefore, shots must be administered frequently, in
Note: The substance ephedrine hydrochloride is also part of numerous injectable solutions, drops, nasal sprays, syrups, ointments, powders, and fluids which, however, are not listed here since athletes usually prefer tablets.
Ephedrine belongs to the group of sympathomimetics. Although it is not a hormone compound, we would still like to describe it briefly since it offers the athlete three interesting effects. First, ephedrine has clear fatburning characteristics. On the one hand, this occurs since ephedrine produces heat in the body (thermoge- nesis). Simplified, ephedrine slightly increases the body temperature so that the body burns more calories than usual. On the other hand, ephedrine stimulates the thyroid gland to transform the weaker LT-4 (L-thyroxine) into the stronger LT-3 (liothyronine), thus accelerating the metabolism. The fatburning effect, with the additional intake of both methylzanthine caffeine and aspirin, can almost be doubled. Scientific research has shown that the combination of 25 mg ephedrine, 200 mg caffeine, and 300 mg aspirin is ideal to produce a synergetic effect. Those who apply this combination three times daily, approximately 30 minutes prior to a meal, will significantly burn fat. Competing bodybuilders have appreciated this for quite some time. Second, ephedrine has anticatabolic characteristics. Thus if is especially useful for maintaining the muscle system while dieting. Finally, athletes often use ephedrine as a “training booster.” Since it has a mild amphetamine-like effect on the central nervous system (CNS) it improves the concentration, vigilance, and the interplay of nerves and muscles. For this purpose, 25-50 mg ephedrine are taken approximately one hour before a workout. The athlete feels an immediate boost in energy which during workout can manifest itself in a 5-10% increase in strength. Again, also in this case, the effect can be improved by taking caffeine and aspirin (s.a.). It is important to note that ephedrine, administered for this purpose, is not to be taken more than three times a week; otherwise, the body gets accustomed to it and the “boost effect” decreases, and much higher dosages are needed.
Side effects can manifest themselves in the form of more rapid heart beat, insomnia, tremors (light trembling of the fingers), headaches, dizziness, high blood pressure, and lack of appetite. The last characteristic, however, is much appreciated by athletes on a diet. Ephedrine must not be taken when high blood pressure, a severe hyperfunction of the thyroid gland, irregular heart rhythm, or a recent myocardiac infarction are present. In Europe ephedrine is a prescription drug which is mostly available in combination with other substances. Such a combination compound, for example, is the German drug Perspiran N, which contains an additional 25 mg ephedrine hydrochloride and 125 mg theophylline per tablet. Theophylline increases the effect of ephedrine. The Spanish Efedrina Level of Laboratorio Level S.A. Company can be found on the black market. A 50 mg tablet usually costs $ 10. The tablets are indented, with “EFEDRINX stamped on the back. Twenty-four tablets are packaged in a small white plastic box with a pull-off label. It is interesting to note that in the U.S. the substance ephedrine hydrochloride is not a prescription drug and is freely available while other stimulants and medicines used in sports are either unavailable or available only at high risk on the black market. In special magazines for bodybuilders one can always find ads freely offering Ephedrine. Until the time that this condition changes, Ephedrine is of no importance on the black market.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide