Dinandrol is a product of Xelox Pharma Co. in the Philippines. Xelox is a licensed drug company, although most of its steroid products are developed for export sales only. The packaging for Dinandrol lists the indicated uses for the drug as being aplastic anemia, anemia caused by cytotoxic drugs, or anemia caused by chronic renal failure. Owing to the fact that Deca-Durabolin is also approved for use in anemic patients in many markets, this drug could be viewed as a cheaper and often acceptable (although not ideal) therapeutic alternative. Still, it is estimated that the majority of steroid product that is traded on the international market is diverted to off-label use by athletes and bodybuilders, usually in Europe and the United States, so it is uncertain how widely this drug is dispensed to legitimate patients. Dinandrol is occasionally smuggled into the United States, though remains more widely distributed on less tightly controlled European markets.
How is Dinandrol Supplied
Dinandrol is manufactured by Xelox Pharma in the Philippines. It contains 100 mg/mL of steroid in oil in a 2 mL vial.
Structural Characteristics of Dinandrol
Dinandrol contains a mixture of two nandrolone compounds, which where modified with the addition of carboxylic acid esters (propionic phenyl ester and decanoic acids) at the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.
Dinandrol Side Effects (Estrogenic)
Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Consequently, estrogen related side effects are a much lower concern with this drug than with testosterone. Elevated-estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.
It is of note that nandrolone has some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.
Dinandrol Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral, enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissue-building actions making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen.
Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN). The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.
Dinandrol Side Effects (Hepatotoxicity)
Nandrolone is not c-17 alpha alkylated, and not known to have hepatotoxic effects. Liver toxicity is unlikely.
Dinandrol Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels. This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate. Nandrolone injectables, however, should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active tardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Dinandrol Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100 mg per week of nandrolone decanoate for 6 weeks have demonstrated an approximate 57% reduction in serum testosterone levels during therapy. At a dosage of 300 mg per week, this reduction reached 70%. It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked in spite of a low tendency for estrogen conversion. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Dinandrol Administration (Men)
To treat aplastic anemia, prescribing guidelines recommend a dosage of 50-200 mg per week. A 200 mg per week dose is recommended for anemia due to renal failure or cytotoxic therapy. When used for physique- or performance-enhancing purposes, a dose of 200-600 mg per week is most common, taken in cycles 8 to 12 weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength, which should be accompanied by a low level of estrogenic and androgenic activity. Due to the fast-acting nature of nandrolone phenylpropionate, the total weekly dosage is often divided into two separate applications, spaced several days apart. Note that as a nandrolone injectable, Dinandrol seems to fit well for both bulking and cutting purposes, and can reasonably replace Deca-Durabolin in most cycles.
Dinandrol Administration (Women)
To treat aplastic anemia, prescribing guidelines recommend a dosage of 50-200 mg per week. A 100 mg per week dose is recommended for anemia due to renal failure, and 200 mg per week for anemia caused by cytotoxic therapy. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week is most common, which is taken for 4 to 6 weeks. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound, even when taking recommended therapeutic doses. Should virilizing side effects become a concern, the drug should be discontinued immediately to help prevent their permanent appearance. After a sufficient period of withdrawal, the shorter acting nandrolone Durabolin® might be considered a safer (more controllable) option. This drug stays active for only several days, greatly reducing the withdrawal time if indicated.
Dinandrol is commonly found on the black market. Its packaging is unique, and would seemingly be difficult and costly to duplicate. To begin with, the product carries a sticker bearing the company logo, which, once removed to open the box, reads VOID. You also open the box to find the vials sitting in a clear-plastic tray that bears the firm's name (Xelox). It is not printed on the tray but molded directly into the plastic, which would obviously be some task for an underground manufacturer to duplicate.
Wlliam Llewellyn (2017) - Anabolics