Drug Class: Herbal thyroid stimulator. (Oral)
Average Reported Dosage: (Standardized for 10% forskolin) 165-250 MG 3-4 times daily.
*Significant stimulation of thyroid gland and adenylate cyclase production.
Why is an herbal supplement in a book intended to report upon the things hardcore athletes have done? It should be recalled that most AAS synthesis begins with a plant extract as does ephedrine, methamphetamine, and heroin. The point being that powerful things come from many places…sometimes.
Coleus Forskohlii increases cyclic AMP (cAMP) in cells and up-regulates thyroid gland function. Why is cellular cAMP so cool? The active substrate in Coleus Forskohlii is a diterpene derivative called forskolin. Well, forskolin stimulates the production of an enzyme called Adenylate-Cyclase (AC) which is sort of a master enzyme in the body that positively effects many other enzymes that regulate muscle growth and fat loss. In this case, AC increases cAMP which in turn activates Protein- Kinase (PK). This event allows a PK/phosphorylation reaction resulting in the active form of Hormone-Sensitive-Lipase (HSL). Finally …HSL stimulates the release of fatty acids from adipose tissue (fat cells) so muscle cells can use them as an energy (ATP) and fuel for heat source. Remember, UCP-3's earlier in this section? Well, forskolin stimulates thyroid gland activity similarly to Thyroid-Stimulating-Hormone (TSH). TSH is also sometimes called thyrotropin. When the thyroid gland stimulated it begins the thyroid hormone cascade by releasing T-4 and so on. Since this results in an increase in circulatory thyroids hormone levels and an increase in (yup!) UCP-3's, more of that newly released fatty acids supply is burned off. The reason the basic biochemistry was explained here is simple. First, anything that affects any of the biochemicals we briefly discussed, also effects body composition. This includes all thermalgenics, AAS, insulin, GH, and most other anabolic chemistries. Second, the basic knowledge may prevent the reader from falling for supplement ad scams by knowing why something will or will not actually have value.
Most products containing Coleus Forskohlii should be (but rarely actually are) standardized for a 10% forskolin content. An effective dosage of the 10% standardized product has been 165-250 MG, 3-4 times daily. So far there is some existing research that supports the listed effects of Coleus Forskohlii. And anecdotal /personal evaluations are positive thus far. It seems finding an actual standardized source is the most difficult aspect of acquiring favorable results.
A note of interest.
The use of Coleus Forskohlii seems to have possible cardiovascular benefits by acting as a vasodilator (lowers blood pressure) , inhibition of platelet aggregation (reduced blood clotting), and positive inotropic activity in the heart (increased contractile force).
The use of Coleus Forskohlii does not seem to inhibit endogenous TSH production. There is a synergy between this product and beta-andrenergic drugs such as Clenbuterol, ephedrine, synephrine, and norephedrine.
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference