Clonidine HCL History
Clonidine first appeared in clinical studies during the late 1960s, and was approved by the U.S. Food and Drug Administration for prescription sale in 1974. Over the years, its favorable safety profile and level of efficacy have allowed it to become a somewhat common first-line option for the treatment of hypertension. The most widely known trade name for clonidine is Catapres, sold in many different countries by the international pharmaceutical manufacturer Boehringer-Ingelheim. In the United States, clonidine products are also available through many generic drug manufacturers including Actavis, Bertek, Global, Mutual, Mylan, Par, Qualitest, UDL Laboratories, Unichem, and Xanodyne.
How is Clonidine HCL Supplied
Clonidine hydrochloride is most commonly supplied in oral tablets of 0.1, 0.2, and 0.3 mg each.
Structural Characteristics of Clonidine HCL
Clonidine is an alpha-agonist hypotensive agent derived Clonidine is an alpha-agonist hypotensive agent derived from imidazoline. It has the chemical designation 2,6- dichloro-N-2-imidazolidinyldenebenzenamine.
Clonidine HCL Warnings
Abrupt discontinuation of clonidine may result in side effects including rebound hypertension, nervousness, agitation, headache, and/or tremor. In rare instances clonidine withdrawal has been associated with serious cerebrovascular accident and even death. Patients should not discontinue clonidine treatment without consulting their physician. When discontinuing clonidine, it is usually advised to slowly reduce the dosage over a minimum period of 2-4 days to reduce withdrawal symptoms.
Clonidine HCL Side Effects
Common side effects associated with clonidine treatment include dry mouth (40% of patients during clinical studies), drowsiness (33%), dizziness (16%), constipation (10%), and sedation (10%). Less frequent adverse reactions include physical fatigue, fever, increased sensitivity to alcohol, abnormal heart beat, congestive heart failure, delirium, insomnia, nightmares, paraesthesia (tingling of the skin), hair loss, rash, abdominal pain, anorexia, hepatitis, vomiting, decreased libido, erectile dysfunction, frequent waking to urinate during the night (nocturia), leg cramps, muscle pain, blurred vision, and dryness or burning of the eyes. Some side effects appear to be dose-dependant. Taking more than the prescribed amount (overdosage) may result in serious adverse reactions including hypotension (low blood pressure), respiratory depression, impaired motor reflexes, weakness, drowsiness, hypothermia, heart irregularities, coma, or death.
Clonidine HCL Administration
When used medically to treat hypertension, the dosage must be tailored to the individual needs of the patient. The usual initial starting dosage in adults is .1 mg given twice daily, morning and evening (.2 mg per day). This dosage may be increased once per week by .1 mg/day until the proper maintenance dosage is achieved. An effective therapeutic maintenance dosage usually rests between .2 mg and .6 mg per day, although a small percentage of patients require significantly higher amounts (2.4 mg/day is considered the maximum therapeutic dosage).
When used by bodybuilders to offset elevated blood pressure due to anabolic/androgenic steroid use, therapeutic use guidelines are usually followed. Some users will initiate clonidine at sub-therapeutic dosages (.1 mg per day) if they are unsure of their responsiveness to the drug, or their relative need for a hypotensive agent. Individuals should be reminded that it is important to monitor blood pressure closely whenever taking any medications that can have hypertensive or hypotensive effects.
Clonidine HCL Availability Trends
Clonidine is widely sold throughout the developed world. Low demand, low cost, and high availability make this drug a low-profit target for counterfeiting. Counterfeits are unlikely to be a significant problem.
This is a drug used to treat high blood pressure (antihypertensive). Bodybuilders and other athletes using AAS often experience this problem due to increased water retention and elevated blood counts. The reason this drug is included here is simple: It raises serum levels of GROWTH HORMONE (GH) by stimulating production from the pituitary gland. Some athletes reported taking 0.3 mg -0.15 MG on an empty stomach both when going to bed and upon waking with a total of 0.18 mg per day, maximum. Personally I disliked the drug due to its many negative side effects such as potency problems, laziness, vertigo, and a few others. The use of antihypertensive drugs without a doctor's guidance is dangerous. Those prone to low blood pressure could die, those with high blood pressure could miss the safe dosage and do the same.
Newbies Research Guide reference
Catapres is an antihypertensive drug. In school medicine it is used to reduce high blood pressure. High blood pressure caused by steroids can be lowered by taking Catapres. Athletes became interested in this drug when medical research reported that Catapres stimulates the endogenous production of the growth hor- mones. It should also be taken before going to sleep at night and in the morning immediately after getting up. Some athletes take a 0.3-mg tablet at night and a 0.15-mg tablet on an empty stomach immediately after waking up in the morning. The nightly dose increases the concentration of growth hormones for several hours, which then again can be increased by taking the morning dose. The achieved serum concentration is significantly above the normal value so that Catapres does have a considerable anabolic effect. Athletes, however rarely use it since it has several undesirable side effects such as lethargy, fatigue, dry mouth, potency disturbances, and vertigo those who have a low blood pressure and a low heart rate should be extremely careful when using it. One hundred tablets are available for approx. $60. on the black market.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Newbies Research Guide